摘要 |
Title compds. I≮X = H, halogen; Y = H, F, Me; R = COOH; R4 = Cl, F, OH; R5 = H, R2,R3 = H, alkyl, aryl; R6,R7 = H, alkyl, alkoxy, formyl, phenyl, cyano; R8 = H, or CH-C9C10(R9,R10 = H, alkyl)≉, useful as local antiinflammatory, were prepared by oxidizing 21-hydroxysteroid I (R = CH2OH). Thus, a mixt. of 9-fluoro-11β,21-dihydroxy pregna-1,4-dieno≮15α,17-d≉cyclohexen-3,20-dione 1.2 g, methanol 150ml and CuNO3 300mg was stirred for 1 hr at room temp. to give 9-fluoro-11β-hydroxy-3,20-dioxopregna-1,4-dieno-≮16α,17-d≉cyclohexene-21-oic acid methyl ester.
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