发明名称 |
6-AMINO-SPIRO[PENAM-2,4'-PIPERIDINE]-3- CARBOXYLIC ACID DERIVATIVES |
摘要 |
<p>6-Amino-spiro¢penam-2,4'-piperidine!-3-carboxylic acid derivatives having the formula wherein R is a methyl, phenyl or benzyl radical, Z1 is a hydrogen atom and Z2 is a radical selected from those known from penicillin chemistry and is preferably a 2phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl 3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl radical, or Z1 and Z2 together represent a bivalent radical Z3 and preferably a (hexahydro-lH-azepin-1-yl)-methylene radical, as well as the pharmaceutically acceptable non-toxic salts thereof and process for preparing the same. These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.</p> |
申请公布号 |
CA1148144(A) |
申请公布日期 |
1983.06.14 |
申请号 |
CA19800354562 |
申请日期 |
1980.06.23 |
申请人 |
U C B, S.A. |
发明人 |
RODRIGUEZ, LUDOVIC;LECLERCQ, JACQUES;YKMAN, PIERRE A.;COSSEMENT, ERIC |
分类号 |
C07D499/46;A61K31/43;A61K31/431;A61P31/04;C07D499/00;C07D499/64;C07D499/68;C07D499/74;C07D499/76;C07D499/80;C07D499/90;(IPC1-7):C07D499/44 |
主分类号 |
C07D499/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|