| 摘要 |
NEW MATERIAL:The physiologically active substance CH-1 having the following properties. Constitution, composed of at least C, H, O and N; elemental analysis, C 38.49%, H 6.07% and N 1.39%; molecular weight, nonpermeative to cellophane membrane and S=6.15S; melting point, develops color at 240 deg.C; specific rotation,[alpha]D<29>-9.52 (c=1, water); solubility, soluble in water and insoluble in organic solvents such as methanol; color reaction, positive to anthrone reaction, etc. and negative to Folin-Lawry reaction, etc.; appearance, white powder; protein content, none; sugar content 53% in terms of glucose. USE:A physiologically active substance having interferon inducing capability and carcinostatic activity. PROCESS:Chlorella belonging to Chlorella genus, e.g. Chlorella pyrenoidosa, etc. is extracted with hot water. The extract liquid is added with a hydrophilic organic solvent to effect the solvent precipitation fractionation. The resultant precipitate is dissolved in water, and dialyzed. The dialyzed solution is subjected to the adsorption chromatography and gel filtration to obtain the objective physiologically active substance CH-1.
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