发明名称 |
DERIVATIVES OF 1-ARYLOXY-3-ALKYLAMINO-2-PROPANOL AND METHODS FOR THEIR PREPARATION |
摘要 |
This invention relates to compounds of the formula <IMAGE> (I) wherein R1 represents a linear or branched alkyl of from 1 to 20 carbon atoms; R2 represents a hydrogen or halogen atom, a linear or branched alkyl or alkoxy of from 1 to 4 carbon atoms, or a divalent group -CH=CH-CH=CH- or -(CH2)n-, in which n is an integer of from 3 to 5, with the free valences bonded in the o-position relative to one another; and R3 represents a linear or branched alkyl of from 3 to 10 carbon atoms, with the provisos that R3 is not tert.butyl when R1 is ethyl or propyl and R2 is a hydrogen atom and that R3 is not isopropyl when R1 is propyl and R2 is a hydrogen atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of Formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia. |
申请公布号 |
DE3160202(D1) |
申请公布日期 |
1983.06.01 |
申请号 |
DE19813160202 |
申请日期 |
1981.03.26 |
申请人 |
C.H. BOEHRINGER SOHN |
发明人 |
KOPPE, HERBERT, DR.;KUMMER, WERNER, DR.;STAHLE, HELMUT, DR.;MUACEVIC, GOJKO, DR.;TRAUNECKER, WERNER, DR. |
分类号 |
C07C253/30;A61K;A61K31/045;A61K31/13;A61K31/135;A61K31/16;A61K31/165;A61K31/275;A61P9/08;A61P9/12;C07C;C07C33/00;C07C67/00;C07C231/00;C07C253/00;C07C255/59;C07C255/60;C07D239/42;C07D239/47;C07D239/52;C07D239/70;C07D251/12;C07D251/46;C07D491/048;C07D491/052;(IPC1-7):C07C121/80;A61K31/27 |
主分类号 |
C07C253/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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