发明名称 |
Process for the production of 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole |
摘要 |
The present invention provides a process for the preparation of 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole by condensing 5-(4'-chloro-5'-sulfamoyl-2'-aminophenyl)-tetrazole with thiophene-2-aldehyde in the presence of an acid catalyst and reducing the 5-[4'-chloro-5'-sulfamoyl-2'-(thenylidene-2-amino)-phenyl]tetrazole so obtained with a boranate, wherein the condensation is carried out in dimethyl sulfoxide as solvent, with azeotropic distilling off of the water formed and the reduction is carried out in the same medium, without isolation of the 5-[4'-chloro-5'-sulfamoyl-2'-(thenylidene-2-amino)-phenyl]-tetrazole.
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申请公布号 |
US4386212(A) |
申请公布日期 |
1983.05.31 |
申请号 |
US19810289934 |
申请日期 |
1981.08.04 |
申请人 |
BOEHRINGER MANHEIM GMBH |
发明人 |
BAETZ, FRIEDRICH;LAUER, KARL |
分类号 |
C07D409/12;C07D257/04;(IPC1-7):C07D257/04 |
主分类号 |
C07D409/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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