Process for the preparation of a biologically active substance for selective inhibition of the proliferation of leukemic and normal myeloid cells

摘要

The invention relates to a process for the preparation of a biologically active substance, which can be isolated from normal white blood cells and is capable of inhibiting the proliferation of normal and leukemic myeloid cells selectively. The substance obtained is a peptide, which has an amino acid composition of Tau1, Asx1, Ser2, Thr1, Glx3, Gly2, Ala1, (PO4)12-, a negative charge at pH 6.5, an electrophoretic mobility of -0.55 to -0.65 related to aspartic acid, has no charge at pH 1.9, has a mobility of about 0.26 related to epsilon -DNP-lysine and gives a positive chloro-toluidine reaction.