| 摘要 |
PURPOSE:To obtain the titled useful compound having a physiological activity in high yield by one process, by reacting an inexpensive and easily obtainable 3-aminomethylindole as a raw material with carbon monoxide and hydrogen in the presence of a catalyst of a metal (compound) of VIII group. CONSTITUTION:A compound shown by the formulaI(R1-10 are H, halogen, hydroxyl group, alkoxy, cyano, acyl, aryl, or 1-20C alkyl; R7 and R8 or R9 and R10 may be linked through a saturated or unsaturated carbon chain) is reacted with carbon monoxide and hydrogen in the presence of a catalyst comprising at least one of a metal or a metal compound of elements of VIII group such as iron, ruthenium, cobalt, etc. in a solvent such as preferably dioxane, etc. at normal temperature -300 deg.C, preferably 30-200 deg.C, to give a compound shown by the formula II. 1H-Indole-3-methanamine, N,N-dimethyl-1H-indole-3-methanamine, etc. may be cited as the concrete examples of the compound shown by the formulaI. |
