Pyrrolo[2,3-d]pyrimidines, process for their preparation and their use as medicaments

摘要

Pyrrolo[2,3-d]pyrimidines of the general formula I <IMAGE> in which R represents hydrogen or preferably an optionally substituted alkyl group, R<1> represents hydrogen, mercapto, alkoxy, optionally substituted alkylmercapto, alkylamino, dialkylamino, optionally substituted arylamino, aralkylamino, pyrrolidinyl, piperidinyl, N-methylpiperazinyl, morpholinyl or pyrryl, or, if R is not hydrogen, but an optionally substituted alkyl group, represents hydroxyl, chloro or amino, R<2> and R<3> are identical or different and each represent alkyl or phenyl which is optionally substituted by halogen, trifluoromethyl, alkyl or alkoxy or together represent an alkylene chain having 2 to 5 carbon atoms, which is optionally substituted by alkyl, R<4> represents hydrogen, halogen, a nitro group, a lower alkyl or alkoxy group or a trifluoromethyl group, R<5> represents hydrogen, halogen or a lower alkyl or alkoxy group, their acid addition salts, a process for their preparation and their use as medicaments, in particular as anti-inflammatories and as agents for the treatment of diseases of the central nervous system.