SELECTIVE HYDROGENATION PRODUCTA OF C-076 COMPOUNDS AND DERIVATIVES THEREOF

摘要

The invention provide compounds having the formula: in which R1 is iso-propyl or sec-butyl; R2 is methoxy, hydroxy or loweralkanoyloxy; and R3 is hydrogen; lower alkanoyl; alpha -L-oleandrosyl; 4 min -(lower alkanoyl)- alpha -L- oleandrosyl; 4 min -( alpha -L- oleandrosyl)- alpha -L-oleandrosyl or 4Rx-(lower alkanoyl)-4 min -( alpha -L- oleandrosyl)- alpha -L- oleandrosyl. These compounds are derivatives of C-076 and are produced by catalytic reduction of the 22,23-position of the C-076 molecule. Further reaction of the reduced C-076 compounds is also possible. The compounds thus produced are used for their profound anthelmintic, insecticidal, ectoparasiticidal and acaracidal activity. Compositions containing the described C-076 derivatives as active ingredient are also disclosed.