FREMGANGSMAATE VED FREMSTILLING AV NYE TERAPEUTISK VIRKSOMME BENZOTHIAZOLINFORBINDELSER

摘要

PCT No. PCT/JP82/00363 Sec. 371 Date Apr. 14, 1983 Sec. 102(e) Date Apr. 14, 1983 PCT Filed Sep. 10, 1982 PCT Pub. No. WO83/00865 PCT Pub. Date Mar. 17, 1983.This invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: [I] wherein R1 is lower alkanoyl; R2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogeno-lower alkyl and sulfamoyl; R3 is R6 is hydrogen, alkyl, substituted alkyl, alkanoyl, substituted alkanoyl, alkenoyl, substituted alkenoyl or furylcarbonyl; R7 is hydrogen, hydroxy, phenyl-lower alkyl or banzoyl; Z is strainght or branched alkylene containing 1 to 6 carbon atoms; m is 0 or 1; n is 0 or 1; and p is 5.