| 摘要 |
Broad spectrum cephalosporin antibiotics represented by the formula <IMAGE> are provided. In the formula, R represents a 2-aminooxazol-4-yl, 5-amino-1,2,4-oxadiazol-3-yl, or 5-aminoisoxazol-3-yl heterocyclic group; R' is hydrogen, C1-C4 alkyl, a carboxy-substituted alkyl or cycloalkyl group or a C1-C4 alkyl ester or carboxy-protecting ester derivative thereof; or an N-substituted carbamoyl group; and R1 and R2 are independently hydrogen or a substituent group, eg. halo, hydroxy, amino, carbamoyl, alkyl, or trifluoromethyl. The antibiotics are useful in a method for treating bacterial infections and can be formulated into pharmaceutical formulations for such use.
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