摘要 |
<p>The new compounds of the formula <CHEM> where R1 and R2 independently are <CHEM> with the proviso at least one of R1 and R2 must be <CHEM> Y1 is F, Cl N(CH3)2 or C1-C4 alkoxy; Y2 is H, F, Cl; R3 is H, <CHEM> 2-tetrahydropyranyl, 2-tetrahydrofuranyl, <CHEM> R6 is C1-C3 alkyl, benzyl, -CH2CH2OCH3 or <CHEM> R7 is C1-C4 alkyl or benzyl; and Ar is <CHEM> where Y3 is H, F, Cl, Br, C1-C4 alkyl, C1-C4 alkoxy or nitro; e.g. 4,5-bis(4-fluorophenyl)-2-nitroimidazole; or their pharmaceutical suitable salts have antiinflammatory activity. A method for preparation of these compounds, involving nitration of 4,5-disubstituted-1-(substituted) imidazoles in 2-position, is given. </p> |