| 摘要 |
NEW MATERIAL:A compound of formulaI(R1 is H, lower alkyl; R2, R3 are lower alkyl, amino) and its salt. EXAMPLE:10-( 4-t-Butoxycarbonylamino-1-piperidinyl )-9-fluoro-3-methyl-7-oxo-2, 3- dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid. USE:Antibacterial: it has strong antibacterial effect against gram-negative and gram-positive bacteria including Pseudomonas areuginosa and is expected to be used as a drug. PREPARATION:A compound of formula II is made to react with, e.g., more than 2mol of an amine in a polar solvent such as DMSO, DMF, DMA, sulfolane or water at room temperature to 200 deg.C, preferably at 70-150 deg.C in accordance with the reaction equations to give the compound of formulaI. |
