摘要 |
1,163,102. D - Ribofuranose derivatives. MERCK & CO. Inc. 8 Nov., 1966 [15 Nov., 1965], No. 49923/66. Heading C2C. Novel D-ribofuranose derivatives of the Formulµ I and III where R is a C 1-4 alkyl radical, X is a halogen atom or a hydroxy, C 1-4 alkoxy, alkanoyloxy, aroyloxy, alkoxyaroyloxy, haloaroyloxy or nitrobenzoyloxy radical and each of R<SP>1</SP>, R<SP>11</SP> and R<SP>111</SP> is a hydrogen atom, or an alkanoyl, aroyl, alkoxyaroyl, haloaroyl or nitrobenzoyl radical provided that, in Formula I, when X is an alkanoyloxy, aroyloxy, alkoxyaroyloxy, haloaroyloxy or nitrobenzoyloxy radical R<SP>1</SP>, R<SP>11</SP> and R<SP>111</SP> are not hydrogen atoms, are obtained by treating 5-O-R<SP>1</SP>-1,2-O-alkylidene-D-erythro- 3-pentulofuranoses with C 1-4 alkyl magnesium halides to give compounds of Formula III in which R<SP>11</SP> is a hydrogen atom, and, if desired, converting these to other compounds of the above formulµ by (a) subjecting them to acid alcoholysis to produce C 1-4 -alkyl-5-O-R<SP>1</SP>-3- C 1-4 alkyl-D-ribofuranoses, acylating these and subjecting the acylated products to hydrolysis or halogen replacement reactions, or (b) acylating them, hydrolysing the isopropylidene group and further acylating the products. |