| 摘要 |
<p>A new semi-synthetic antibiotic, 3''-deoxystreptomycin is now provided, which is useful as an antibacterial agent and is produced from 3''-deoxydihydrostreptomycin by a process comprising oxidizing the 3'-hydroxymethyl group of 2,5,6,4'',6''-penta-O-acetyl-2''-N-benzyloxycarbonyl-3''-deoxydihydros treptomycin as prepared by skilled introduction of amino-protecting group and hydroxyl-protecting group of appropriately selected natures into 3''-deoxydihydrostreptomycin, and then removing the protective groups from the oxidation product, 2,5,6,4'',6''-penta-O-acetyl-2''-N-benzyloxycarbonyl-3''-deoxystreptom ycin.</p> |
