发明名称 |
Preparation of 7-acylamino-3-(thio-substituted)-methyl 3-cephem-4-carboxylic acid-1-oxide derivatives |
摘要 |
A novel process for the preparation of 7-acylamino-3-(thio-substituted)-methyl-3-cephem-4-carboxylic acid 1-oxide derivatives comprising reacting a 7-acylamino-3-bromomethyl-3-cephem-4-carboxylic acid-1-oxide derivative with a silylated thiol of the formula R-S-Si(CH3)3 I wherein R is an organic group, preferably a 5- or 6-membered heterocyclic group, which reaction is preferably carried out in the presence of an inert organic solvent at a temperature between -20 DEG and 80 DEG C. to obtain the corresponding 7-acylamino-3-(R-thiomethyl)-3-cephem-4-carboxylic acid-1-oxide derivatives, which are valuable intermediates in methods for the preparation of therapeutically active cephalosporins.
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申请公布号 |
US4379923(A) |
申请公布日期 |
1983.04.12 |
申请号 |
US19810297214 |
申请日期 |
1981.08.28 |
申请人 |
GIST-BROCADES N.V. |
发明人 |
BRUYNES, CORNELIS A.;JURRIENS, THEODORUS K. |
分类号 |
C07D499/00;C07D501/04;C07D501/36;C07F7/08;C07F7/10;C07F7/18;C07F9/24;C07H23/00;C07J51/00;(IPC1-7):C07D501/04 |
主分类号 |
C07D499/00 |
代理机构 |
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代理人 |
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地址 |
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