| 摘要 |
<p>Cephems I(R1=H, (un) substituted alkyl, acyl, arylsulfonyl, alkylsulfonyl, amino-protective group; R2=H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl, heterocycle; R3=H, esterforming group, cation; R4=H, alkoxy; A=H, (un) substituted alkoxy or alkenoxy, halo, alkyl; X=S, O, CH2, NH), useful as antimicrobial agents were prepd. I(R=R3=R4=H; R1=Me, Et; R2=H, Na; X=S) are esp. effective against Pseudomonas. E.g., dicyclohexylcarbodiimide-midiated coupling of 2-synmethoxyimino-2-(2tritylamino-4-thiazolyl) acetic acid with 7-aminoceph-3-em-4-carboxylic acid, followed by purifn. via the (H2NCH2)2 salt, gave I(R, R2-R4=H, R1=Me)</p> |
