| 摘要 |
PURPOSE:To prepare the titled compound useful as a coccidiostatic agent, selectively, in high yield, by reacting a metallic salt of N<6>-substituted adenine with benzyl halide. CONSTITUTION:The N<6>-substituted adenine metal salt of formulaI(R is H, 1-4C lower alkyl or 5-7C aralkyl; R' is 1-4C lower alkyl or 5-7C aralkyl; M is alikali metal or alkaline earth metal; n>=1) is made to react with the benzyl halide of formula II (X is Cl or Br; Y and Z are H, Cl, Br, or F) in the presence of a phase transfer catalyst[e.g. the quaternary ammonium salt of formula III (R1-R3 are 1-18C alkyl; R4 is 1-10C alkyl, etc.; X is OH, etc.), etc.]to obtain the objective 9-substituted compound. By the use of the metallic salt of formulaIas a starting raw material, the production of the 3-substituted compound of formula V can be suppressed, and the selectivity of the 9-substituted compound can be increased. The presence of the phase transfer catalyst increases the rate of the main reaction, and prevents the side reactions. |
