发明名称 |
Vasodilative 4-thia-PGI1 and 4-sulfinyl-PGI1 and derivatives thereof |
摘要 |
A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formula A 4-thia- or 4-sulfinyl-PGI1-compound of the formula I <IMAGE> (I) wherein Q stands for -S- or -SO-, A stands for C1-6 straight or branched chain alkylene, B stands for ethylene, vinylene or ethinylene, R1 represents hydrogen or C1-4 alkyl, R2 represents C1-8 straight or branched chain alkyl or mono-substituted aryl-oxy-methyl, R3 stands for hydrogen or acetyl, and Z represents -COOH, -CN, -CH2OH or -COOW, wherein W stands for an equivalent of a pharmacologically acceptable cation or C1-4 alkyl.
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申请公布号 |
US4379164(A) |
申请公布日期 |
1983.04.05 |
申请号 |
US19810314433 |
申请日期 |
1981.10.23 |
申请人 |
CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. |
发明人 |
TOEMOESKOEZI, ISTVAN;GYOERY, PETER;KOVACS, GABOR;VIRAG, SANDOR;KOERMOECZY, PETER;STADLER, ISTVAN |
分类号 |
C07D307/935;A61K31/557;A61K31/5575;A61P1/04;A61P9/08;A61P11/08;C07C405/00;C07D307/937;(IPC1-7):A61K31/33;C07D307/93 |
主分类号 |
C07D307/935 |
代理机构 |
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