C-SUBSTITUTED NAPHTHALENEMONOSULFONIC UREIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention provides novel C-substituted naphthalenemonosulfonic ureides and pharmaceutical compositions containing them. The novel compounds of the invention have the formula: wherein A is hydrogen or a pharmaceutically acceptable salt cation; B is hydrogen, lower (C1-C6) alkanoyl or alkali metal; and R is hydrogen or lower (C1-C3) alkyl. The present novel compounds are especially useful for inhibiting connective tissue destruction in warm-blooded animals and for such purpose may be formulated with pharmaceutically acceptable carriers or diluents e.g. to form dental creams and pastes.