1.2.4-TRIAZOLIDINE-3.5-DIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Coumpounds of the formula (I) wherein: n is 1 to 5 Y is -CH2-CH2, -CH=CH- or -C IDENTICAL C- R1 is hydrogen or CO2R1 represents an ester group in which the R1 moiety contains from 1-12 carbon atoms; R2 is hydrogen, C1-4 alkyl or phenyl; R3 is hydroxy or protected hydroxy; R4 is a group of the formula: L-Q-R10 in which Q is an oxygen atom, a -CH=CH- group or a -C IDENTICAL C- group, and L is a C1-9 alkylene group; and R10 is C1-4 alkyl, phenyl or naphthyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkyl, hydroxy, C1-6 alkoxy, phenyl C1-6 alkoxy or nitro groups, or if Q is a -CH=CH- group, the R10 may be a hydrogen atom; and R5 is hydrogen or C1-6 alkyl; and salts thereof, having similar activity to natural prostaglandins, a process for their preparation, intermediates useful in that process and pharmaceutical compositions containing them.