| 摘要 |
<p>NEW MATERIAL:A compound of formulaI[X is CH2, S or O; Y is OH, acyloxy, etc.; A is phenyl, naphthalene, etc.; R1 is H, OH, etc.; R2 is H, CH2R2' (R2' is H, azido, etc.), etc.; R3 is H, alkali metal, etc; R4 and R5 are H, lower alkyl, etc,; l is 0, 1, 2 or 3; m is 0 or 1; n is 1, 2, 3, 4 or 5]. EXAMPLE:(6R, 7S)-7-[2-(2-Aminothiazol-4-yl )-2-syn-( 3,4-diacetoxybenzoyloxyimino) acetamido]-1-azabicyclo[4.2.0]oct-2-ene-8-oxo-2-carboxylic acid. USE:An antimicrobial agent. PROCESS:A novel compound of formula II (Z is amino or protected amino; Y' is Y, protected OH, etc.) or a reactive derivative thereof, e.g. acid chloride, is condensed with a compound of formula III (R3' is R3, etc.) to give a compound of formula IV, which is then subjected to the removal of the protecting group to afford the compound of formulaI.</p> |
