发明名称 |
N-Methyl-D-glucamine salt of with 3,4-dihydro-5-methyl-6-(2-methylpropyl)-4-oxothieno[2,3-d]pyrimidine-2-carboxylic acid |
摘要 |
Treatment of the antiallergic agent 3,4-dihydro-5-methyl-6-(2-methylpropyl)-4-oxothieno[2,3-d]pyrimidine-2 -carboxylic acid with N-methyl-D-glucamine gives a salt with improved solubility. Solutions of this salt have pH values in a range acceptable for topical formulations. Additionally, solutions of the subject salt exhibit good stability which can be demonstrated by retention of potency. The salt is comprised of a 1:1 molecular ratio of the glucamine base to the acid.
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申请公布号 |
US4377583(A) |
申请公布日期 |
1983.03.22 |
申请号 |
US19810294962 |
申请日期 |
1981.08.21 |
申请人 |
MEAD JOHNSON & COMPANY |
发明人 |
LARSEN, AUBREY A.;OWENS, DONALD A. |
分类号 |
A61K31/505;A61P27/16;A61P37/08;C07D495/04;(IPC1-7):C07D513/04;A61K31/50 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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