| 摘要 |
<p>There are disclosed novel thiadiazole oxide compounds having the formula: <CHEM> wherein: B<1> is R A/ &cir& (CH2)n X (CH2)m -; and, B<2> is R <CHEM> wherein: R is hydrogen, loweralkyl: <CHEM> wherein R1 and R2 are independently e.g. hydrogen, loweralkyl, cycloloweralkyl, or phenylloweralkyl, or R1 and R2 may be joined to form, along with the nitrogen to which they are attached, a 5- or 6-membered heterocycle; R3 and R4 are independently hydrogen or loweralkyl; n is 0 or 1; m is 2 to 4; k is 1 to 4; X is oxygen, sulfur or methylene; p is 1 or 2; A/ &cir& is phenylene or a 5- or 6-membered heterocycle containing one to three heteroatoms selected from oxygen, sulfur or nitrogen, which may optionally have a benzo ring fused thereon; provided that when A/ &cir& is a 5-membered heterocycle or benzo fused 5-membered heterocycle, n is 1 and processes for the preparation of such compounds. The compounds are useful for the suppression of gastric acid secretions in mammals.</p> |
