| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I (R<1> and R<2> are protecting group; R<3> is aryl; B<1> and B<2> are basic residue which may contain protective group). EXAMPLE:P-2-Chlorophenyl-5'-O-dimethoxytritylthymidyl-3'-O-[ (2-chlorophenylo xy-2-methylphenylthio )phosphino ]-( 3' 5' )thymi-dine. USE:Astructural intermediate for oligodeoxynucleotide. PREPARATION:For example, a deoxynucleoside phosphoric ester derivative shown by formula II is reacted with a deoxynucleoside to give an oligonucletide shown by formula IV, which is reacted with a 1,2,4-triazolyllphosphine compound shown by formula V to give a compound shown by formula I.</p> |
