| 摘要 |
Pyrroloquinolines(I; R1 = H, C1-3 alkyl; R2 = C1-3 alkyl or allyl; R3 = H, or CH2X; X = CN, CONH2, SO2CH3,SCH3,OCH3), useful as dopamine potentiators, were prepd. by the reaction of Id(R1 = C1-3 alkyl-CO) and base. Thus, 4.4 g 4-benzoyloxycyclohexanone and 2.5 ml n-propylamine were refluxed in 100 ml toluene for 2 hr, followed by addition of 4 ml acrylic acid in 100 ml dioxane, and refluxed overnight to give 2.15 g 1-n-propyl-6-benzoyloxy-3,4,5,6,7,8-hexahydro-2(1H)-quinoline and 1-n-propyl-6-benzoyloxy-3,4,4a,5,6,7-hexahydro-2(1H)-quinoline.
|
