| 摘要 |
A process for preparing an ergoline of the formula <IMAGE> wherein C9----C10 is a CC single or double bond, R1 is hydrogen or CONR2, R being hydrogen, methyl, or ethyl, and wherein NR' is in the alpha - or beta - position, R2 is lower alkyl of up to 3 carbon atoms, and the salts thereof, comprises treating the corresponding ergolinyl carboxylic acid amide with lead(IV) acetate in an aprotic polar solvent; reacting the intermediarily formed corresponding isocyanate with water or with a reactive amine of up to 4 carbon atoms, (e.g. a mono- or dialkylamine of up to 4-C atoms); and, optionally, treating the resultant product with an acid to form the corresponding salt. |
