摘要 |
Compounds of the formula:
<CHEM>
wherein
R<1>, which is attached to a carbon atom of ring "B", is hydrogen, halo, C1-C4 alkyl, or -S(C1-C4 alkyl);
Y, which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 alkyl) or -CONH2;
X is O, S, NH, N(C1-C4 alkyl) or -CH=CH-;
and
R, which is attached to carbon atom of ring "B", is a group of the formula:
<CHEM>
where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-;
and the pharmaceutically, acceptable salts thereof.
<??>The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates.
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