INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS

摘要

The invention relates to new indole derivatives which possess interesting pharmacological properties and in particular a lipid-lowering and an antiatherosclerotic acitivty. The compounds of formula I I wherein either R1 represents a hydrogen atom, a C1-C12 alkyl group or a C3-5 alkenyl group and R2 represents a hydrogen atom, a C1-3 alkyl group (optionally substituted by a phenyl group), a phenyl group (optionally substituted by a halogen atom or a methoxy, amino, nitro or acetamido group) or a pyridyl group, or R1 and R2 together represent a C3-5 alkylene group; R3 represents a hydrogen atom, a C1-3 alkyl group (optionally substituted by a pyridyl group or by a phenyl group, said phenyl group itself optionally being substituted by a methyl, methoxy or trifluoromethyl group or by a halogen atom), a phenyl group (optionally substituted by a halogen atom or a methyl, methoxy or trifluoromethyl group), a pyridyl or pyridyl-N-oxide group or a quinolyl group; with the proviso that when one of R2 and R3 represents a hydrogen atom the other represents other than a hydrogen atom or a C1-3 alkyl group; R4 represents a carboxyl or nitrile group, a trialkoxymethyl group wherein each alkoxy group may contain from 1 to 3 carbon atoms, a C2-8 alkoxycarbonyl group, an aminocarbonyl group (optionally substituted by one substituent or two substituents which may be the same or different selected from C1-7 alkyl groups, C3-7 cycloalkyl groups and C3-7 alkenyl groups) or a hydroxymethyl, piperidinocarbonyl, morpholinocarbonyl or thiomorpholinocarbonyl group; R5 represents a C1-3 alkyl group; R6 represents a hydrogen atom or a methyl or benzyl group; and R7 represents a hydrogen atom or a methyl group.