THE TREATMENT AND PREVENTION OF SCOURS IN ANIMALS

摘要

The husbandry of calves, lambs, foals or adult cattle may be improved by the administration, in order to combat scours, of a compound of the formula: [wherein either R1 is phenyl, substituted phenyl, aralkyl, pyridyl or substituted pyridyl and R2, R5 and R6 are hydrogen, lower-alkyl, substituted-lower-alkyl, hydroxy, lower-alkoxy, lower-alkenyl, cyclo-lower-alkynyl, cyclo-lower-alkyl, lower-alkynyl, alkyl-sulphonyl or aralkyl-sulphonyl, with R5 and R5 optionally forming a 5 or 6 membered heterocyclic ring which may include 1 or 2 additional hetero atoms; or R5 is as R1 above and R6, R1 and R2 are respectively as R2, R5 and R6 above; and R3 and R4, which may be the same or different, are hydrogen, lower-alkyl, lower-alkoxy, lower-alkenyl, lower-alkynyl, cyclo-lower-alkyl or aralkylBD ¨& or an addition salt thereof. The preferred coumpounds (I) are those wherein R5 is 2,6-disubstituted-phenyl, and especially 1-(2,6-dimethyl-phenyl)-3-methylamidinourea and its hydrochloride salt. The compounds (I) are preferably administered orally or by injection in the form of liquid compositions containing electrolyte; or by incorporation of the compounds (I) in the daily dietary intake of the animals.