| 摘要 |
Cephalosporin deriv.(I) was manufd. by reacting 7-aminocephalosporin or its reactive deriv. on substituted ureidophenyl acetic acid(II). Thus. D(-)α-(3-Me-1-ureido)-α-phenylacetic acid 6.4 g produced by reacting N-methylisocyanate on D(-)-phenylglycine and trimethylsylyl chloride 7 g were added into tetrafuran 50 ml. Triethylamine 4.4 g was dropped. After stirred for 1 hr at 40-50≦̸C and cooled to 10≦̸C, tetrafuran soln. 20 ml contg. 3,4-diacetoxybenzoyl chloride 7.9 g was dropped, stirred for 2 hr at 50≦̸C, cooled to 10≦̸C and filtered non-soluble material. A filtered soln. was concd., purified the residue and obtained the desirable deriv.
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