| 摘要 |
Novel peptides having the following amino acid sequence X-Y1-Z1-E1-G1-J1-Q (I) X-Y2-Z2-E2-G2-J2-Q (II) X-Y3-Z3-E3-G3-J3-Q (III) X-Y4-Z4-E4-Q (IV) X-Y5-Z5-E5-J5-Q (V) X-Y6-Z6-E6-J6-Q (VI) X-Y7-Z7-E7-G7-J7-Q (VII) X-Y8-Z8-E8-G8-Q (VIII) X-Y9-Z9-E9-G9-J9-Q (IX) X min -Y10-Z10-E10-G10-J10-L10-Q (X) and the pharmaceutically acceptable salts thereof, wherein X is selected from a group consisting of -NH2, -NHCH3, and -N(CH3)2; Y1, G1, Y2, G2, E4, Z5, J5, Y6, G6, Z7, G7, Y8, G8, Y9, Y10 and G10 are selected from a group consisting of tyrosine tryptophan, and phenylalanine; Z1, J1, Z2, Z3, E3, Y4, Z4, E5, G5, E6, J6, Y7, E7, Z8, E8, E8, Z9, E9, Z10 and J10 are selected from a group consisting of D-tyrosine, D-tryptophan, and D-phenylalanine; J3 and Z6 are selected from a group consisting of glycine, alanine, valine, leucine, isoleucine, proline, hydroxyproline, serine, threonine, cysteine and methionine; E1 is selected from a group consisting of glycine, alanine, valine, leucine, isoleucine, proline, hydroxyproline, serine, threonine, cysteine, methionine, aspartic acid, glutamic acid, asparagine, glutamine, and histidine; E2 is selected from a group consisting of glycine, alanine, valine, leucine, methionine, and isoleucine; J2 is selected from a group consisting of glycine, alanine, D-alanine, valine, D-valine, leucine, D-leucine, isoleucine, D-isoleucine, proline, D-proline, hydroxyproline, D-hydroxyproline, serine, D-serine, threonine, D-threonine, cysteine, D-cysteine, methionine, and D-methionine; Y3 is selected from a group consisting of tyrosine, D-tyrosine, tryptophan, D-tryptophan phenylalanine, and D-phenylalanine; G3 is selected from a group consisting of lysine and arginine; Y5 is selected from a group consisting of D-lysine and D-arginine; J7 is selected from a group consisting of glycine, alanine, valine, leucine, isoleucine, proline, hydroxyproline, serine, threonine, cysteine, methionine, aspartic acid, glutamic acid, asparagine, glutamine, arginine, and lysine; |
