发明名称 NEW SUBSTITUTED 3-(PARASUBSTITUTED)PHENOXY-1-ALKYLAMINO-PROPANOL-2-S, AS WELL AS PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING SAME, AND METHOD FOR TREATING CARDIAC FAILURE
摘要 Compounds of the formula I <CHEM> wherein R<3> is selected from the group consisting of hydrogen or methyl, m is an integer 0 or 1, whereby when m is 0, R<4> and R<3> are the same and are selected from the group consisting of methoxy, fluoro, bromo, and chloro in 2- and 6-position, whereby when m is 1, R<4> is hydrogen and R<5> is selected from the group consisting of hydrogen, methoxy, ethoxy, acetyl, methyl, hydroxymethyl, cyano, chloro, fluoro, bromo, or hydroxy, or a pharmaceutically acceptable salt thereof, as well as their preparation, pharmaceutical preparations containing the same, and method of treating cardiac failure. The compounds which possess beta-adrenoceptor stimulating activity are intended for treatment of cardiac disease whereby the compounds possess a pronounced inotropic effect.
申请公布号 ZA8202729(B) 申请公布日期 1983.02.23
申请号 ZA19820002729 申请日期 1982.04.21
申请人 AB HAESSLE 发明人 CARLSSON E;GUSTAFSSON B;KAELLSSON B;MATTSSON A
分类号 C07C217/34;A61K;A61K31/13;A61K31/135;C07C;C07C67/00;C07C213/00;C07C217/60;C07C253/00;C07C255/54 主分类号 C07C217/34
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