| 摘要 |
PURPOSE:To obtain the titiled substance in high yield in high selectivity useful as a a raw material for synthesizing a physiologically active substance or other syntheses, by reacting a para-position substituted phenol with an allyl chloride in the presence of cyclodextrin as a catalyst. CONSTITUTION:A para-position substituted phenol derivative is reacted with an allyl halide derivative in the presence of cyclodextrin as a catalyst, to give a compound shown by the formula (A, B, C, D and E are H, substituted or unsubstituted alkyl, aryl, alkoxyl, or allyl; R is substituted or unsubstituted allyl). To be concrete, cyclodextin is added to the para-position substituted phenol derivative and an aqueous solution of NaOH, etc., and dissolved, the allyl halide is added to the solution dropwise, to give the compound shown by the formula. alpha-Cyclodextrin or beta-cyclodextrin can be used as the cylcodextrin. After the desired substance is separated, the reaction system is acidified, it is precipitated and directly can be reused. |
