发明名称 Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
摘要 The invention relates to a heterocyclic derivative of the formula: <IMAGE> I where D is O, S or NH; E is CH or when D is O or S, E is N; Y is S, O, CH2, SO or a direct bond; m is 0 to 4 and n is 1 to 4, provided that when Y is S, O or SO m is 1 to 4, when Y is O or SO, n is 2 to 4; A is C(3-4) chain comprising at least one C and also optionally S, N, 2N or N and S, and also comprising C=O or C=S or where possible SO2, the chain optionally substituted by 1 or 2 C(1-6) alkyl, benzyl, naphthylmethyl, 2-phenethyl, 4-phenylbutyl, pyridylmethyl, thiazolylmethyl, thienylmethyl, benzyloxy, pyridylmethoxy or phenoxymethyl radicals each optionally substituted on the aromatic ring system by 1 to 3 halogen atoms or methyl, methoxy, trifluoromethyl, dimethylamino, phenyl or phenoxy radicals; and the salts thereof.
申请公布号 US4374836(A) 申请公布日期 1983.02.22
申请号 US19790083479 申请日期 1979.10.10
申请人 IMPERIAL CHEMICAL INDUSTRIES LTD.;ICI AMERICAS INC. 发明人 YELLIN, TOBIAS O.;JONES, DERRICK F.
分类号 C07D417/12;A61K31/425;A61K31/505;A61P1/00;A61P1/04;C07D213/58;C07D239/47;C07D253/06;C07D277/48;C07D417/00;C07D417/14;(IPC1-7):A61K31/50 主分类号 C07D417/12
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