Pyridoxine derivatives, and use in therapeutics

摘要

Novel pyridoxine derivatives represented by the general formula: <IMAGE> in which: R represents a radical <IMAGE> -CH2-(CH2)n-CH2-OR2 or <IMAGE> in which n represents 0 or 1, X and X1, which are different, represent hydrogen or methyl, Y represents hydrogen or methyl and R2 represents a phenyl group non-substituted or bearing one or two substituents selected from the group consisting of fluorine, chlorine and bromine and of the radicals methyl, ethyl, n-propyl, isopropyl and methoxy, R1 represents hydrogen or a radical of formula <IMAGE> in which R3 represents a straight-chain alkyl radical having from 1 to 4 carbon atoms and pharmaceutically acceptable acid addition salts thereof. These compounds present alpha -antiadrenergic properties some of them also presenting beta -antiadrenergic, antihypertensive and central depressant effects.