发明名称 |
FREMGANGSMAADE TIL FREMSTILLING AF N-(S-3-ALKYLHEPTANYL)-D-GAMMA-GLUTAMYL-GLYCYL-D-ALANIN OG MELLEMPRODUKTER TIL BRUG VED FREMGANGSMAADEN |
摘要 |
acid and analogues of formula (I) are new. R is CH2OR1, CH2OH, CHO, COOH or COCl or another activated form of the acid COOH; R1 is H or silyl hydroxy protecting gp. Alanine derivs. of formula (II) and their cationic salts when R2 and R3 are H are new. R2=R3=H; pr R2,R3=1-6C alkyl, 6-8C cycloalkylmethyl or benzyl. Prepn. of an acid or ester of formula (III) comprises coupling an activated form of (I) with an amino acid ester of formula (IV) to form a cpd. (II), followed by hydrogenation to reduce the double bond and remove the benzyl gp.(s). R4=R5=H; or one=H and the other=1-6C alkyl or 6-8C cycloalkylmethyl; R6=R7=PhCH2; or one of R6 and R7=PhCH2 and the other=1-6C alkyl or 6-8C cycloalkylmethyl. |
申请公布号 |
DK444887(A) |
申请公布日期 |
1988.02.28 |
申请号 |
DK19870004448 |
申请日期 |
1987.08.26 |
申请人 |
PFIZER INC. |
发明人 |
MURTIASHAW, CHARLES WILLIAM |
分类号 |
C07F7/18;B01J25/02;B01J27/125;C07B31/00;C07B53/00;C07B57/00;C07C;C07C27/00;C07C29/88;C07C33/025;C07C33/03;C07C45/00;C07C47/21;C07C51/00;C07C51/09;C07C51/16;C07C53/126;C07C57/03;C07C57/66;C07C67/00;C07C69/533;C07C229/00;C07F7/02;C07K;C07K1/00;C07K1/02;C07K1/113;C07K5/02;C07K5/04;C07K5/06;C07K5/08;C07K5/10;(IPC1-7):C07C57/03 |
主分类号 |
C07F7/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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