| 摘要 |
There is described a process for the preparation of novel androstadiene-17 beta -carboxylic acid esters of the formula <IMAGE> in which R denotes the radical of an alcohol ROH of the aliphatic, araliphatic or heterocyclic series having 1-10 C atoms, R' denotes a hydroxyl group which is free or esterified with a carboxylic acid having at most 7 C atoms, R'' denotes an alpha - or beta -methyl group or the methylene group or R' with R'' together denote the 16 alpha ,17 alpha -dihydroxyacetonide group <IMAGE> X denotes chlorine and Y denotes chlorine or fluorine. The compounds of the formula (I) have anti-inflammatory activity. According to the invention, they are obtained by converting a carboxylic acid of the formula (I), in which R represents hydrogen and the other substituents have the abovementioned meanings, or a salt thereof or a functional derivative thereof which can be converted into an ester into the carboxylic acid ester.
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