| 摘要 |
The present invention provides a process for the production of compounds of formula I, <IMAGE> in which n is 2, 3, 4 or 5 R1 is ethyl or vinyl, and either R2 and R3 are the same or different and each signifies alkyl of 1 to 4 carbon atoms, or R2 and R3, together with the nitrogen atom to which they are attached, form a heterocyclic ring optionally containing a second hetero moiety selected from oxygen, sulphur or =N-R5, in which R5 is alkyl of 1 to 4 carbon atoms, or an acid addition salt form thereof, comprising reacting a compound of formula II, <IMAGE> in which R1 is as defined above, and R6 is alkyl of 1 to 4 carbon atoms or phenyl, unsubstituted or substituted by alkyl of 1 to 4 carbon atoms, with a compound of formula III, <IMAGE> in which n, R2 and R3 are as defined above, characterised in that the reaction is effected in the presence of a phase transfer catalyst, and, where required, converting a resulting free base form of the compounds of formula I into an acid addition salt form, or vice versa. The compounds of formula I are indicated for use as antibiotics having an antibacterial effect and are also indicated for use as prophylactic additives for animal feeding stuffs and animal drinking water. |
