PROCESS FOR THE PREPARATION OF(DL)-16-PHENOXY-AND-16-SUBSTITUTED PHENOXY-9-KETO PROSTATRIENOIC ACID DERIVATIVES

摘要

Title compds. (I; R = halo, Me, or MeO; R1 = H, C1-4 alkyl, or salt moiety) were prepd.; the key step was lipase hydrolysis of the ester group. Thus, (±)-II was silylated, oxidized, desilylated, and hydrolyzed with pancreatic lipase to give (±)-I(R=R1=H).