Antiinflammatory 2:phenyl imidazo pyrimidine(s) - prepd. from 2:amino pyrimidine and an alpha bromo propiophenone

摘要

2-Phenyl imidazo (1,2-a)pyrimidines of formula (I) and their non-toxic salts are new. (where R1 and R2 is H or halogen; R3 is H, halogen, CH3S-, CH3SO-, or CH3SO2-, at least 1 or R1,R2 and R3 being other than H; R4 is 1-4C alkyl). (I) are prepd. by reacting (II) and (III). Reaction may be carried out in hexamethyl phosphorotriamide, using an excess of (II). (I; R3 is CH3S-) may be oxidised to give the analogous sulphinyl and sulphonyl derivs. Useful as anti-inflammatories, esp. for treatment of arthritis. LD50 values are above 1000mg/kg p.o.(mouse).