| 摘要 |
<p>derivs. of formula (I) and their salts are new (where R1 and R2 are H or lower alkyl, or R1+R2 is 2-5C alkylene; R3 is H, lower alkyl, benzyl or Ar, where Ar is phenyl opt. monosubstd. by halogen, lower alkyl or lower alkoxy; A is 2-4C alkylene; Y is dialkylamino, pyrrolidino, 1-alkylpyrrolidinyl, piperidino, 4-hydroxy-4-phenylpiperidino, 4-hydroxy-4- (halophenyl)piperidino, morpholino or 4-R-1-piperazinyl, where R is lower alkyl, benzyl, pyridyl or Ar', and Ar' is phenyl opt. monosubstd. by halogen, lower alkyl, haloalkyl or alkoxy). Intermediates of formula (II) are also claimed (where R1-R3 are as defined above, except that R2 is not alkyl and R1-R3 cannot all be H). 6 Cpds. (I), including 6-(2-(4-(2- chlorophenyl)-1- piperazinyl)ethyl) -5,6,7,8-tetrahydro- 3-methyl-1,6- naphthyridine (Ia) are specifically claimed. (I) have anti-vertiginous and central muscle relaxant activity, the latter generally being higher than that of tolperisone. Effective doses are 1-500 (pref. 5-100) mg/day.</p> |
