发明名称 |
PROCEDEU DE OBTINERE A UNOR ANTIBIOTICE NACROLIDE |
摘要 |
<p>23,Demycinosyloxytylosin and its 20-dihydro deriv. of formula (I) (where Q is CHO or CH2-OH, respectively) and their acyl esters, and their acid-addn. salts are new. Streptomyces fradiae NRRl 12171 is new. A culture medium contg. Strep.fradiae NRRL 12171 and assimilable sources of C, N and inorganic salts is new. (I) are antimicrobials esp. effective against Gram-positive bacteria and Mycoplasma spp., e.g. in poultry. Cpds. (I) are obtd. by cultivation under submerged aerobic conditions of Strep.fradiae NRRL 12171 in a nutrient medium. The (I; Q is CHO) may be reduced to give (I; Q is CH2-OH). On mild acid hydrolysis (I) give 23-deoxy-5-0- mycaminosyltylonolide or its 20-dihydro deriv. Cpds. (I) may be acylated, selectively or fully, by known methods. NRRL 12171 was obtd. by chemical mutagenesis of a tylosin- producing strain of Strep.fradiae.</p> |
申请公布号 |
RO81017(A) |
申请公布日期 |
1983.02.01 |
申请号 |
RO19810104536 |
申请日期 |
1981.06.09 |
申请人 |
ELI LILLY AND CO,US |
发明人 |
MALTZ,RICHARD H.,US;WILD,GENE M.,US;SENO,EUGENE T.,GB;KIRST,HERBERT A.,US |
分类号 |
C12P1/06;A61K31/70;A61K31/7042;A61K31/7048;A61P31/04;C07H17/08;C12P17/08;C12P19/62;C12R1/465;(IPC1-7):12P17/08 |
主分类号 |
C12P1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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