| 摘要 |
<p>HOE 79/F 114 A METHOD OF PREPARATION OF LOWER ALKYL 4,10-DIHYDRO-10-OXOTHIENO¢3,2-c!¢1!BENZOXEPIN-8-ACETATE of the disclosure: Lower alkyl 4,10-dihydro-10-oxothieno¢3,2-c!¢1!-benzoxepin-8-acetate is synthesized from 4-(2-carboxy-3-thienylmethoxy)phenylacetic acid by a process comprising acid halide formation, ring closure catalyzed by aluminum trihalide and esterification with a lower alcohol. The three reaction steps are carried out successively in the same reactor without any isolation or purification of intermediate products and a surprisingly high overall yield is obtained additionally, significant advantages in terms of environmental pollution and waste water costs are achieved.</p> |
