3-AMINO-4-HOMOISOTWISTANE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

摘要

3-Amino-4-homoisotwistane derivatives of the formula,

wherein R1 is hydrogen or an alkyl or alkenyl group, and R2 is an alkyl or alkenyl group, or non-toxic pharmaceutically acceptable salts thereof, are prepared by reacting a 3-R1-amino-4-homoisotwistane with R3X where R3 is alkyl, alkenyl, carboalkoxy or alkanoyl and X is halogeno and reducing any carboalkoxy or alkanoyl group in the reaction product to an alkyl group or are prepared by reacting 3-bromo-4-homoisotwistane with R1R2NH. The compounds and salts, which can be formulated into pharmaceutical compositions, are valuable as antiviral agents for animals and useful for the treatment of perkinsonean disease.