摘要 |
Compounds of formula <CHEM> wherein, R1 and R2 are hydrogen, alkyl, cycloalkyl, alkylthio, halo, -CF3, CF3S-, phenyl optionally substituted by halogen, alkyl or alkoxy, -CH2NR4R5 or -SO2NR6R7 or R1 and R2 joined together form -(CH2)n-, n= 3 or 4, R3 is hydrogen, alkyl, cycloalkylalkyl, cycloalkyl or alkanoyl and Y is hydrogen, halo, -CN, -CF3), alkyl, alkoxy or -COOH, prepared by reaction between halo-imidazo (1,2-a) pyrazines with piperazine derivatives, are found to be active anorexic, antidepressant, antihypertensive. analgesic, antiarrhythmic, and/or antismoking agents. |