| 摘要 |
Compounds of formula (I): <CHEM> and salts and in vivo hydrolysable acyl derivatives thereof, wherein R<1> is hydrogen or methyl; R<2> is hydrogen or methyl; R<3> is phenyl unsubstituted or substituted with one or two of the following:- fluorine, chlorine, bromine, trifluoromethyl, C1-6 straight or branched chain alkyl or C1-6 straight or branched chain alkoxy; or is benzofuran-2-yl; R<5> is a hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; R<4> is moiety <CHEM> wherein X is C2-10 alkylene which may be straight or branched provided that the oxygen and nitrogen are separated by at least two carbon atoms, A is hydrogen; C1-6 straight or branched alkyl or benzyl optionally substituted with halogen, lower alkyl or lower alkoxy. R<6> is hydrogen; C1-6 straight or branched alkyl; C1-6 straight or branched alkylsulphonyl - @ - R<7>; R<7> is C1-6 straight or branched alkyl; C1-6 straight or branched alkoxy; amino, mono- or di- (C1-6 straight or branched alkyl) amino; or <CHEM> is a 5,6 or 7 membered cyclic amine optionally containing a second hetero atom selected from oxygen, nitrogen and sulphur, and n is 1 or 2 have anti-obesity and antihyperglycaemic activity.
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