发明名称 IMPROVED ANTIBODY AND PREPARATION THEREOF
摘要 PURPOSE:To obtain an antibody having excellent specificity to materials to be examined, etc. by inducing immunity non-responsiveness by dosing of the covalent bonded material of the 2nd antigen and a D-glutamic acid-D-lysine copolymer to mammals then immunizing the same with the 1st antigen. CONSTITUTION:The covalent bonded material of the 2nd antigen having >=1 antigen determining groups similar to the 1st antigen in structure and a copolymer of D-glutamic acid and D-lysine (D-GL) is dosed to mammals to induce the immunity non-responsiveness to said 2nd antigen is said animals, after which said animals are immunized with said 1st antigen. Then said material has high specificity to the 1st antigen and a low cross characteristic with said 2nd antigen. The intended antibody is obtained. A copolymer of, for example, about 27000- 120000mol.wts. and about (70:30)-(30:70)molar ratios between the D- glutamic acid and the D-lysine is used for said D-GL.
申请公布号 JPS589069(A) 申请公布日期 1983.01.19
申请号 JP19810107981 申请日期 1981.07.10
申请人 HAMAOKA TOSHIYUKI 发明人 HAMAOKA TOSHIYUKI;TATEISHI KAYOKO
分类号 A61K38/00;A61K39/00;G01N33/531 主分类号 A61K38/00
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