发明名称 Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group.
摘要 The (5-R-2-oxo-1,3-dioxolen-4-yl)methyl moiety: <CHEM> wherein R is loweralkyl of 1-6 carbon atoms, especially methyl or t-butyl; when utilized as an ester on a pharmaceutical having a carboxylic acid functionality, enhances oral absorption of the pharmaceutical. This effect is applicable to a broad range of pharmaceutically active substances, including antibiotics, and antihypertensives as well as other classes of therapeutic agents.
申请公布号 EP0070013(A1) 申请公布日期 1983.01.19
申请号 EP19820106172 申请日期 1982.07.12
申请人 MERCK & CO. INC. 发明人 BURTON, CHRISTENSEN G.
分类号 C07D317/40;C07D499/88;C07D501/20;C07F7/08;C07F9/655;(IPC1-7):C07D501/04;C07D501/57;C07D499/00;A61K31/00;C07F9/40;C07D405/12 主分类号 C07D317/40
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