| 摘要 |
Proliferative skin diseases such as psoriasis are treated by topically administering cAMP analogs of the following formula to the afflicted skin site at a dose that preferentially and significantly activates type II protein kinase: <IMAGE> where: R6 is: (i) -NR1 R2 where R1 and R2 are independently selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, and cyclopentyl or are joined together with the nitrogen atom to form a hetrocyclic group having 4 to 5, inclusive, annular carbon atoms with the proviso that the total number of carbon atoms in the -NR1 R2 group is 4 or 5, or (ii) -XR where X is a chalcogen atom of atomic number 8 or 16 and R is alkyl of 4 or 5 carbon atoms, R8 is: (i) -X-(CH2)n R3 where X is defined previously, n is an integer in the range of 1 to 3, inclusive, R3 is hydrogen, alkyl of 1 to 7 carbon atoms, or phenyl substituted with 0 to 1, inclusive, nitro, halo of atomic number 9 to 35, inclusive, methoxy, hydroxy or methyl, or (ii) -NR4 R5 wherein R4 and R5 are independently selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, and phenalkyl of 7 to 9 carbon atoms with the provisos that only one of R4 and R5 may be hydrogen and the total number of carbon atoms in the -NR4 R5 group is in the range of 1 to 9, inclusive, and Z is hydrogen, an alkali metal cation or ammonium.
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